October 18, 2007Stem CellsOpen Access

Peroxisome Proliferator-Activated Receptor α Agonists Enhance Cardiomyogenesis of Mouse ES Cells by Utilization of a Reactive Oxygen Species-Dependent Mechanism

Q: What is the clinical evidence from this study?

Population: Cardiomyogenesis of embryonic stem cells. Intervention: PPARalpha agonists (WY14643, GW7647, and ciprofibrate) vs. PPARalpha antagonist MK886, PPARbeta/gamma agonists, or untreated. Primary outcome: Cardiomyogenesis and expression of cardiac genes.

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Key result

Stimulation of PPARalpha, but not PPARbeta or PPARgamma, enhances cardiomyogenesis in mouse embryonic stem cells via a reactive oxygen species-dependent mechanism.

Population

Mouse embryonic stem (ES) cells

Comparison

PPARalpha agonists vs PPARalpha antagonist, PPARbeta agonist…

Design

Preclinical

Authors

FSFatemeh SharifpanahPhilipps University of Marburg MWMaria WartenbergJena University Hospital MHMadeleine Hannig

Discussion

Member takes

Implication

May advance stem cell cardiomyogenesis protocols; hypothesis-generating with no clinical implications yet.

Structured PICO

Population

Mouse embryonic stem (ES) cells

Intervention

PPARalpha agonists (WY14643, GW7647, and ciprofibrate)

Comparator

PPARalpha antagonist (MK886), PPARbeta agonist (L-165,041), PPARgamma agonist (GW1929), and various inhibitors/scavengers

Outcome

Cardiomyogenesis and expression of cardiac genes (MLC2a, ANP, MHC-beta, MLC2v, and cardiac alpha-actin) and cardiogenic transcription factorssurrogate

Stimulation of PPARalpha enhances cardiomyogenesis in embryonic stem cells through a pathway involving reactive oxygen species and NADPH oxidase activity.

Cite This Study

Sharifpanah et al. (2007) studied Cardiomyogenesis of embryonic stem cells. PPARalpha agonists (WY14643, GW7647, and ciprofibrate) vs. PPARalpha antagonist MK886, PPARbeta/gamma agonists, or untreated was evaluated on Cardiomyogenesis and expression of cardiac genes. Stimulation of PPARalpha, but not PPARbeta or PPARgamma, enhances cardiomyogenesis in mouse embryonic stem cells via a reactive oxygen species-dependent mechanism.

synapsesocial.com/papers/6a7d94ed050e98c0187d81fa https://doi.org/10.1634/stemcells.2007-0532

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Peroxisome Proliferator-Activated Receptor α Agonists Enhance Cardiomyogenesis of Mouse ES Cells by Utilization of a Reactive Oxygen Species-Dependent Mechanism

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Peroxisome Proliferator-Activated Receptor α Agonists Enhance Cardiomyogenesis of Mouse ES Cells by Utilization of a Reactive Oxygen Species-Dependent Mechanism

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider