Synthetic peptides from the amino-terminal part of VP1 are highly reactive and may be useful for developing enterovirus diagnostics or vaccines.
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Animal VP1 epitope mapping may guide peptide diagnostics; leaves open human translation and vaccine utility.
Synthetic peptides were employed in enzyme-linked immunosorbent assays to identify group-common linear epitopes in the structural and nonstructural proteins of enteroviruses.Nine linear epitopes were recognized by using sera from patients with heterotypic immunoglobulin G antibody responses to enterovirus infections.The most-reactive peptides were derived from conserved regions of the amino-terminal part of VP1, whereas peptides representing sequences from other conserved regions ofVP1, as well as VP2, VP3, and VP4, and from a nonstructural region showed no or poor reactivity.These findings may be useful in the development of
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