Usefulness of At Rest and Exercise Hemodynamics to Detect Subclinical Myocardial Disease in Type 2 Diabetes Mellitus
Key result
Inducible myocardial dysfunction during exercise in patients with T2DM was associated with calibrated integrated backscatter (OR 1.08, p=0.04) and lower peak heart rate (OR 0.97, p=0.002).
Population
167 healthy patients with type 2 diabetes mellitus without myocardial ischemia, mean age 55 ± 10 years, 97…
Design
Cross-sectional
Authors
Discussion
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Implication
Highlights non-metabolic contributors to exercise dysfunction in T2DM; hypothesis-generating and requires prospective validation before clinical use.
Study Design
Type
Cross-Sectional (n=167)
Structured PICO
P
Population
167 healthy patients with type 2 diabetes mellitus, free of myocardial ischemia, evaluated for subclinical myocardial dysfunction at rest and during exercise.
E
Exposure
At rest and exercise echocardiography including color tissue Doppler imaging and calibrated integrated backscatter
O
Outcome
Correlates of subclinical myocardial dysfunction at rest and inducible myocardial dysfunction after exercisesurrogate
Main Result
Odds Ratio: 1.08
p-value: p=0.04
In patients with T2DM, resting subclinical myocardial dysfunction is associated with metabolic derangement, whereas an abnormal stress response is associated with nonmetabolic factors like myocardial fibrosis and autonomic neuropathy.
Cite This Study
Jellis et al. (2011) conducted a cross-sectional in Type 2 Diabetes Mellitus (n=167). Clinical and echocardiographic parameters (e.g., calibrated integrated backscatter, peak heart rate) was evaluated on Inducible myocardial dysfunction after exercise (OR 1.08, p=0.04). Inducible myocardial dysfunction during exercise in patients with T2DM was associated with calibrated integrated backscatter (OR 1.08, p=0.04) and lower peak heart rate (OR 0.97, p=0.002).