Why the study?
Does a single oral dose of acetylsalicylic acid prevent platelet adhesion in the injured abdominal aorta of rabbits?
Population
Rabbits with injured abdominal aorta following standard mechanical removal of the endothelium
Comparison
Single oral dose of acetylsalicylic acid (ASA) vs Platelets obtained before treatment
Design
Preclinical
Authors
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ASA does not inhibit in vivo platelet adhesion in rabbit aorta; leaves open whether in vitro collagen assays predict arterial thrombosis responses.
Does a single oral dose of acetylsalicylic acid prevent platelet adhesion in the injured abdominal aorta of rabbits?
A single oral dose of ASA does not prevent platelet adhesion to the subendothelial surface in vivo, despite preventing adhesion to collagen in vitro.
B. L. Sheppard (1972) studied this question.
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