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August 1, 1994Journal of Biological ChemistryOpen Access

Kinetics of lipolysis of very low density lipoproteins by lipoprotein lipase. Importance of particle number and noncompetitive inhibition by particles with low triglyceride content.

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Why the study?

What are the major compositional factors of very low density lipoprotein that determine its properties as a substrate for lipoprotein lipase?

Population

Human very low density lipoprotein, rabbit cholesterol-rich VLDL, and human intermediate density lipoprotein…

Comparison

Lipolysis by lipoprotein lipase vs Different fractions of VLDL and addition of…

Design

Preclinical

Authors

PCPhilip W. ConnellySt. Michael's HospitalGMGraham F. MaguireWestern UniversityCVCamilla VézinaSt. Michael's Hospital

Discussion

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Implication

Highlights VLDL particle number for LPL kinetics in models; leaves open human translation and measurement implications.

Structured PICO

What are the major compositional factors of very low density lipoprotein that determine its properties as a substrate for lipoprotein lipase?

P
Population
Human very low density lipoprotein (VLDL), rabbit cholesterol-rich VLDL, and human intermediate density lipoprotein (IDL) and low density lipoprotein (LDL) from a patient with hepatic lipase deficiency
I
Intervention
Lipolysis by lipoprotein lipase
C
Comparator
Different fractions of VLDL (pre-beta vs beta) and addition of other lipoproteins
O
Outcome
Apparent Km (kinetics of lipolysis)surrogate

VLDL particle number, rather than just triglyceride concentration, is the primary determinant of its properties as a substrate for lipoprotein lipase, with low-triglyceride particles acting as noncompetitive inhibitors.

Cite This Study

Connelly et al. (1994) studied this question.

synapsesocial.com/papers/6a7dc9fd75afeb5dc533969bhttps://doi.org/10.1016/s0021-9258(17)32029-x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mechanism of Action of Lipoprotein Lipase on Triolein Particles: Effect of Apolipoprotein C-II11984 · 30 citations
  2. 2Association of coronary atherosclerosis with hyperapobetalipoproteinemia [increased protein but normal cholesterol levels in human plasma low density (beta) lipoproteins].1980 · 635 citations
  3. 3PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT1951 · 318,705 citations
  4. 4Lipoprotein ApoC-II activation of lipoprotein lipase. Modulation by apolipoprotein A-IV.1990 · 303 citations
  5. 5Apolipoprotein B metabolism in subjects with deficiency of apolipoproteins CIII and AI. Evidence that apolipoprotein CIII inhibits catabolism of triglyceride-rich lipoproteins by lipoprotein lipase in vivo.1986 · 427 citations