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July 5, 1974Science

Failure of Beta-Adrenergic Receptor Blockade to Prevent Arrhythmias Induced by Sympathetic Nerve Stimulation

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Why the study?

Does beta-adrenergic receptor blockade prevent arrhythmias induced by sympathetic nerve stimulation in dogs?

Population

Dogs undergoing electrical stimulation of the ventrolateral cardiac sympathetic nerve to produce cardiac…

Design

Preclinical

Authors

RGRichard A. GillisGeorgetown UniversityDPDavid L. PearleInterventional / Structural CardiologyTHTheodore B. HoekmanMemorial University of Newfoundland

Discussion

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Member takes

Overview

Does not support beta-blockade preventing sympathetic stimulation arrhythmias in dogs; leaves open non-adrenergic mechanisms for study.

Structured PICO

Does beta-adrenergic receptor blockade prevent arrhythmias induced by sympathetic nerve stimulation in dogs?

P
Population
Dogs undergoing electrical stimulation of the ventrolateral cardiac sympathetic nerve to produce cardiac arrhythmias
I
Intervention
Combined administration of propranolol and practolol (beta-adrenergic blockade), alpha-adrenergic blockade, and cholinergic blockade
O
Outcome
Blockade of cardiac arrhythmiassurrogate

Beta-adrenergic, alpha-adrenergic, and cholinergic receptor blockade failed to prevent arrhythmias induced by sympathetic nerve stimulation in dogs, suggesting a novel neuroeffector junction mechanism.

Cite This Study

Gillis et al. (1974) studied this question.

synapsesocial.com/papers/6a7dd09e87be3f923b5ca560https://doi.org/10.1126/science.185.4145.70
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1PROPRANOLOL (INDERAL) IN EXPERIMENTALLY-INDUCED CARDIAC ARRHYTHMIAS1966 · 57 citations
  2. 2Sleep and Ventricular Premature Beats1973 · 221 citations