September 23, 2024Respiratory MedicineOpen Access

PH was associated with increased in-hospital mortality in HFpEF (OR 1.23; 95% CI 1.17-1.28), hypertrophic cardiomyopathy (1.42; 1.06-1.89), mitral regurgitation (1.17; 1.07-1.28), and aortic stenosis (1.14; 1.04-1.26), but not in HFrEF (1.04; 0.99-1.10).

View Full Paper

Ask AI

Bookmark

Why the study?

Pulmonary hypertension associated with left heart disease prevalence varies significantly across studies, with limited real-world evidence on its prevalence and prognostic influence.

Does the presence of pulmonary hypertension increase in-hospital mortality in hospitalized patients with left heart disease?

Population

6,270,625 hospitalizations with left heart disease from the 2018 US Nationwide Inpatient Sample

Comparison

Patients with vs without a secondary pulmonary hypertension diagnosis

Design

Nationwide cross-sectional database analysis

Authors

IFIoannis T. Farmakis LHLukas Hobohm LVLuca Valerio

Discussion

Member takes

Overview

PH-LHD prevalence and prognosis in LHD warrant cautious interpretation from administrative data; leaves open prospective validation of impact.

Structured PICO

Does the presence of pulmonary hypertension increase in-hospital mortality in hospitalized patients with left heart disease?

Population

6,270,625 hospitalizations with left heart disease (heart failure, cardiomyopathies, aortic, and mitral valve disease) from the 2018 US Nationwide Inpatient Sample.

Intervention

Presence of secondary pulmonary hypertension (PH) diagnosis

Comparator

Absence of pulmonary hypertension diagnosis

Outcome

Prevalence of PH-LHD and in-hospital mortalityhard clinical

Pulmonary hypertension is present in 12.8% of hospitalized patients with left heart disease and is associated with increased in-hospital mortality across most forms of LHD, except HFrEF.

Cite This Study

Farmakis et al. (2024) studied this question.

synapsesocial.com/papers/6a7dd466d491aa75eb1510f9 https://doi.org/10.1016/j.rmed.2024.107817

View Full Paper

Ask AI

Bookmark

September 23, 2024Respiratory MedicineOpen Access

PH was associated with increased in-hospital mortality in HFpEF (OR 1.23; 95% CI 1.17-1.28), hypertrophic cardiomyopathy (1.42; 1.06-1.89), mitral regurgitation (1.17; 1.07-1.28), and aortic stenosis (1.14; 1.04-1.26), but not in HFrEF (1.04; 0.99-1.10).

View Full Paper

Ask AI

Bookmark

Why the study?

Pulmonary hypertension associated with left heart disease prevalence varies significantly across studies, with limited real-world evidence on its prevalence and prognostic influence.

Does the presence of pulmonary hypertension increase in-hospital mortality in hospitalized patients with left heart disease?

Population

6,270,625 hospitalizations with left heart disease from the 2018 US Nationwide Inpatient Sample

Comparison

Patients with vs without a secondary pulmonary hypertension diagnosis

Design

Nationwide cross-sectional database analysis

Authors

IFIoannis T. Farmakis LHLukas Hobohm LVLuca Valerio

Discussion

Member takes

Overview

PH-LHD prevalence and prognosis in LHD warrant cautious interpretation from administrative data; leaves open prospective validation of impact.

Structured PICO

Does the presence of pulmonary hypertension increase in-hospital mortality in hospitalized patients with left heart disease?

Population

6,270,625 hospitalizations with left heart disease (heart failure, cardiomyopathies, aortic, and mitral valve disease) from the 2018 US Nationwide Inpatient Sample.

Intervention

Presence of secondary pulmonary hypertension (PH) diagnosis

Comparator

Absence of pulmonary hypertension diagnosis

Outcome

Prevalence of PH-LHD and in-hospital mortalityhard clinical

Pulmonary hypertension is present in 12.8% of hospitalized patients with left heart disease and is associated with increased in-hospital mortality across most forms of LHD, except HFrEF.

Cite This Study

Farmakis et al. (2024) studied this question.

synapsesocial.com/papers/6a7dd466d491aa75eb1510f9 https://doi.org/10.1016/j.rmed.2024.107817

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark