December 1, 1993AJP Heart and Circulatory Physiology
Hemodynamic and mechanical determinants of myocardial O2 consumption in normal human heart: effects of dobutamine
Why the study?
Does dobutamine infusion affect myocardial O2 consumption and mechanical efficiency in healthy volunteers?
Population
8 healthy normal volunteers
Comparison
Dobutamine infusion (5-10 micrograms/kg/min) vs Rest (baseline before infusion)
Design
Other
Authors
Discussion
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Member takes
Implication
Dobutamine may raise O2 demand while lowering efficiency in healthy hearts; leaves open effects in diseased myocardium or on outcomes.
Structured PICO
Does dobutamine infusion affect myocardial O2 consumption and mechanical efficiency in healthy volunteers?
P
Population
8 healthy normal volunteers
I
Intervention
Dobutamine infusion (5-10 micrograms/kg/min)
C
Comparator
Rest (baseline before infusion)
O
Outcome
Myocardial O2 consumption (MVO2) calculated from [1-11C]acetate clearance with positron emission tomographysurrogate
Inotropic stimulation with dobutamine increases myocardial oxygen consumption and decreases the efficiency of contraction in healthy human subjects.
Cite This Study
Vanoverschelde et al. (1993) studied this question.