Why the study?
Does dobutamine infusion induce perfusion-metabolism mismatch in CAD patients with significant LAD stenosis and normal resting contractile function?
Population
18 human subjects: 8 normal subjects and 10 coronary artery disease patients with significant single-vessel…
Comparison
Dobutamine infusion during [11C]acetate positron… vs Resting state; remote myocardial regions; normal…
Design
Cross-sectional
Authors
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Supports stress-induced flow-metabolism uncoupling in CAD; hypothesis-generating for prognostic or therapeutic implications.
Does dobutamine infusion induce perfusion-metabolism mismatch in CAD patients with significant LAD stenosis and normal resting contractile function?
In CAD patients with LAD stenosis, dobutamine stress induces a disparate rise in oxidative metabolism relative to myocardial perfusion, indicating flow-metabolism uncoupling likely due to increased oxygen extraction.
Janier et al. (1996) studied this question.
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