Why the study?
Does congestive heart failure impair myocardial blood flow reserve and cause ischemia in non-stenotic coronary segments compared to normal LV function in patients with CAD?
Population
24 males with coronary artery disease, comprising 12 with congestive heart failure and 12 controls with…
Comparison
Evaluation of myocardial blood flow reserve and… vs Controls with similar CAD but normal left…
Design
Case-control
Authors
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Microvascular ischemia may perpetuate CHF despite non-stenotic arteries; hypothesis-generating for targeted interventions in CAD.
Does congestive heart failure impair myocardial blood flow reserve and cause ischemia in non-stenotic coronary segments compared to normal LV function in patients with CAD?
In patients with heart failure, myocardial blood flow reserve is impaired and ischemia occurs in areas supplied by non-stenotic coronary arteries, suggesting ischemia may perpetuate myocardial failure.
Ad F.M. van den Heuvel (2002) studied this question.
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