Increased Translatable mRNA and Decreased Lipogenesis Are Responsible for the Augmented Secretion of Lipid-deficient Apolipoprotein E by Hepatocytes from Fasted Rats
Population
Rats (livers and hepatocytes)
Comparison
Fasting (drinking water only for three days) vs Control
Design
Preclinical
Follow-up
3 days
Authors
Discussion
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Member takes
Implication
Hypothesis-generating for hepatic apoE regulation in metabolic stress; leaves open human translation and cardiovascular relevance.
Structured PICO
P
Population
Rats (livers and hepatocytes)
I
Intervention
Fasting (drinking water only for three days)
C
Comparator
Control (fed chow plus drinking water for three days)
O
Outcome
apoE mRNA abundance and apoE secretionsurrogate
Fasting increases the secretion of lipid-deficient apoE by rat hepatocytes due to increased translatable mRNA and reduced lipogenesis.
Cite This Study
Davis et al. (1989) studied this question.