Why the study?
Does isoflurane reduce outward Ca2+-activated K+ current in single smooth muscle cells of the guinea pig portal vein?
Population
Single smooth muscle cells of guinea pig portal vein
Design
Preclinical
Authors
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May explain isoflurane vasodilation via IK,Ca inhibition in vascular smooth muscle; animal data leave human relevance open.
Does isoflurane reduce outward Ca2+-activated K+ current in single smooth muscle cells of the guinea pig portal vein?
Isoflurane reduces outward Ca2+-activated K+ current in vascular smooth muscle cells, likely secondary to a reduction in inward Ca2+ channel current, contributing to its vasodilatory effects.
Dixon W. Wilde (1996) studied this question.