PAB1 Self-Association Precludes Its Binding to Poly(A), Thereby Accelerating CCR4 Deadenylation In Vivo

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Population

Saccharomyces cerevisiae (yeast) model

Comparison

Deletion or alteration of PAB1 domains vs Wild-type PAB1 or deletion of other PAB1 regions

Design

Preclinical

Authors

Discussion

PAB1 domain variants modulate mRNA deadenylation in model systems; leaves open relevance to cardiovascular transcript regulation.

Population

Saccharomyces cerevisiae (yeast) model

Intervention

Deletion or alteration of PAB1 domains (proline-rich region, RRM1, RRM3)

Comparator

Wild-type PAB1 or deletion of other PAB1 regions

Outcome

PAB1-PAB1 protein interactions, PAB1 circularization, poly(A) binding, and CCR4 deadenylation ratesurrogate

PAB1 self-association into multimers or circular species precludes poly(A) binding, which accelerates CCR4-mediated mRNA deadenylation in vivo.

Yao et al. (2007) studied this question.

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