Population
Liver biopsy sections from patients with chronic viral hepatitis, nonviral liver disease, and histologically…
Comparison
HBV infection/transfection vs Nonviral liver disease, histologically normal…
Design
Preclinical
Authors
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NOS2 induction by HBV may drive liver injury in chronic hepatitis; leaves open whether NOS2 inhibition alters disease course in patients.
Hepatotropic viral infections upregulate NOS2 gene expression in human hepatocytes, suggesting NO may mediate pathogenic events in chronic viral hepatitis.
Majano et al. (1998) studied this question.
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