Degradation of Nuclear Factor Kappa B during Foot-and-Mouth Disease Virus Infection

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Population

BHK-21 cells and primary porcine cells

Comparison

Infection with wild-type foot-and-mouth disease… vs Infection with a genetically engineered mutant…

Design

Preclinical

Authors

Discussion

May guide L(pro) inhibitor development for FMDV; leaves open efficacy in natural livestock hosts.

Population

BHK-21 cells and primary porcine cells

Intervention

Infection with wild-type foot-and-mouth disease virus (FMDV) expressing leader proteinase (L(pro)) or recombinant cardiovirus expressing L(pro)

Comparator

Infection with a genetically engineered mutant FMDV lacking the leader coding region

Outcome

NF-kappaB-dependent reporter gene expression and degradation of p65/RelAsurrogate

The FMDV leader proteinase L(pro) antagonizes the cellular innate immune response by degrading the p65/RelA subunit of NF-kappaB.

Santos et al. (2007) studied this question.

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