Highlights the importance of considering assay interference in patients with persistently elevated troponin levels and normal coronary arteries.
May warrant checking for assay interference in unexplained troponin elevation; single case leaves open prospective validation.
A 27-year-old woman with chest pain was admitted for elevated troponin levels. Troponin remained mildly elevated upon repeat testing, and a review of the medical record revealed that she had had an elevated troponin level in the past. She had a cardiac catheterisation that revealed angiographically normal coronary arteries. Repeat troponin testing with and without ethylene glycol revealed a negative troponin level after addition of ethylene glycol, suggesting antibodies were interfering with the assay.
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Lefort et al. (2014) studied this question.
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