Population
Adolescent A/J and C57BL/6J mice (susceptible or resistant to myocarditis) and derived immune cells
Comparison
Coxsackievirus B3 (CVB3) infection vs Comparison between A/J and C57BL/6J strains
Design
Preclinical
Follow-up
up to 7 days post-infection
Authors
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Strain differences in CVB3 splenic localization may relate to myocarditis susceptibility; leaves open human translation.
CVB3 replicates in murine splenocytes, specifically B cells and extrafollicular cells, with differences in localization between myocarditis-susceptible and resistant mouse strains.
Anderson et al. (1996) studied this question.
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