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September 1, 1973Circulation Research

Length-Tension Relationship of Smooth Muscle of the Hog Carotid Artery

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Population

Vascular strips teased from the media of hog carotid arteries

Design

Preclinical

Authors

JHJeremiah T. HerlihyThe University of Texas Health Science Center at San AntonioRMRichard A. MurphyUniversity of Southern California

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Overview

No direct clinical implications; leaves open translation of hog carotid mechanics to human vascular function.

Key Points

  • To determine the active and passive length-tension relationships and load-bearing capacity of isolated arterial smooth muscle.
  • Isolated adventitia-free vascular strips from hog carotid artery media, verified to contain 60% smooth muscle cross-sectional area aligned parallel to the strip axis.
  • Evaluated force generation in response to potassium depolarization, norepinephrine, and electric field stimulation across varying muscle lengths.
  • Determined passive length-tension curves after quick-release length adjustments to avoid confounding tone.
  • Potassium-induced depolarization produced the maximum contractile response, whereas norepinephrine and electric field stimulation generated 70% and 30% of this force, respectively.
  • At optimal length (L0), the intrinsic load-bearing capacity (P0) was 2.22 x 10^6 dynes/cm^2, with active tension declining gradually below L0 and dropping rapidly at lengths exceeding L0.
  • Passive tension remained negligible below 0.9 L0 and reached 10% of P0 at L0.

Structured PICO

P
Population
Vascular strips teased from the media of hog carotid arteries
I
Intervention
Potassium-induced depolarization, norepinephrine, and electric field stimulation
O
Outcome
Length-tension relationships and force developmentsurrogate

This preclinical study characterizes the fundamental length-tension relationship and intrinsic load-bearing capacity of arterial smooth muscle in hog carotid arteries.

Cite This Study

Herlihy et al. (1973) studied this question.

synapsesocial.com/papers/6a7e313a7ddcd43fa24f978ehttps://doi.org/10.1161/01.res.33.3.275
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of stretch on passive tension and contractility of isolated vascular smooth muscle1962 · 78 citations
  2. 2Length at Inactivated Contractile Elements, Length‐tension Diagram Active State and Tone of Vascular Smooth Muscle1966 · 66 citations
  3. 3Conduction in smooth muscle: comparative structural properties1960 · 135 citations
  4. 4THE REASON FOR THE SHAPE OF THE DISTENSIBILITY CURVES OF ARTERIES1957 · 685 citations
  5. 5FILAMENT LENGTHS IN STRIATED MUSCLE1963 · 336 citations