April 1, 2005AJP Heart and Circulatory Physiology
Influence of insulin and free fatty acids on contractile function in patients with chronically stunned and hibernating myocardium
Why the study?
Does short-term metabolic modulation with insulin and free fatty acids affect contractile function in heart failure patients with chronically stunned and hibernating myocardium?
Population
8 nondiabetic patients with heart failure, ejection fraction 30 +/- 4% and chronically stunned and…
Comparison
3-hour infusion of insulin-glucose and… vs 3-hour infusion of saline
Design
Other
Follow-up
3 hours per infusion
Authors
Discussion
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Member takes
Implication
Short-term metabolic modulation does not enhance contractility in hibernating myocardium; leaves open whether chronic or alternative substrate strategies benefit HF.
Structured PICO
Does short-term metabolic modulation with insulin and free fatty acids affect contractile function in heart failure patients with chronically stunned and hibernating myocardium?
P
Population
8 nondiabetic patients with heart failure, ejection fraction 30 +/- 4% and chronically stunned (CST) and hibernating (HIB) myocardium in 49 +/- 6% of the left ventricle
I
Intervention
3-hour infusion of insulin-glucose (euglycemic insulin clamp; high insulin, suppressed FFA) and somatostatin-heparin (suppressed insulin, high FFA)
C
Comparator
3-hour infusion of saline
O
Outcome
Global ejection fraction and regional contractile function (maximum velocity [Vmax] and strain rate [epsilon max]) determined by tissue Doppler imaging at steady state and after maximal exercisesurrogate
Short-term metabolic modulation with insulin or free fatty acids does not alter resting or post-exercise contractile function in chronically stunned or hibernating myocardium in patients with heart failure.
Cite This Study
Wiggers et al. (2005) studied this question.