Why the study?
Does verapamil reduce proteinuria as effectively as trandolapril in patients with non-diabetic renal disease?
Population
11 non-diabetic patients with proteinuria, baseline creatinine clearance 87 ml/min, and 24-h blood pressure…
Comparison
Verapamil SR, trandolapril, and their fixed… vs Placebo and active cross-over treatments.
Design
RCT, random cross-over, double-blind
Follow-up
6 weeks per treatment period
Authors
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Verapamil is inferior to trandolapril for proteinuria reduction in non-diabetic renal disease; challenges calcium channel blocker equivalence to ACE inhibitors.
Does verapamil reduce proteinuria as effectively as trandolapril in patients with non-diabetic renal disease?
In non-diabetic renal disease, verapamil is less effective than the ACE inhibitor trandolapril at reducing proteinuria, and its antiproteinuric effect appears dependent on blood pressure reduction.
M.H. Hemmelder (1999) studied this question.
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