Why the study?
Does isoflurane anesthesia inhibit vascular alpha 1-adrenergic responsiveness in patients undergoing coronary artery bypass surgery?
Does isoflurane anesthesia inhibit vascular alpha 1-adrenergic responsiveness in patients undergoing coronary artery bypass surgery?
Isoflurane-induced systemic vasodilation is not mediated via inhibition of alpha 1-adrenergic responsiveness, indicating phenylephrine remains effective for correcting hypotension during isoflurane anesthesia.
No takes yet. Share an insight, caveat, or question.
Supports phenylephrine use for isoflurane hypotension in CABG; hypothesis-generating for alpha1-independent mechanisms and needs larger trials.
Schwinn et al. (1990) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: