Why the study?
Does whole body oxygen extraction ratio remain a valid indicator of myocardial metabolism and transfusion need during acute anemia in the presence of limited coronary vascular reserve?
Population
14 adult dogs, n=7 with critical LAD stenosis and n=7 controls.
Comparison
Critical left anterior descending coronary… vs Normal coronary arteries during isovolemic…
Design
Preclinical
Authors
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Whole-body OER >50% may mark myocardial anaerobic metabolism during anemia despite coronary stenosis; hypothesis-generating for clinical transfusion thresholds.
Does whole body oxygen extraction ratio remain a valid indicator of myocardial metabolism and transfusion need during acute anemia in the presence of limited coronary vascular reserve?
A whole body oxygen extraction ratio greater than 50% remains a valid indicator of myocardial anaerobic metabolism during acute anemia, even in the presence of limited coronary vascular reserve.
Levy et al. (1992) studied this question.
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