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August 1, 1992AJP Heart and Circulatory Physiology

Flow modulates coronary venular permeability by a nitric oxide-related mechanism

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Population

Isolated cannulated coronary venules ranging from 30 to 70 microns in diameter

Comparison

Increased intraluminal flow velocity and… vs Baseline flow velocity and baseline permeability

Design

Preclinical

Authors

YYYonggui YuanChinese Academy of SciencesHGHarris J. GrangerUniversity of SienaDZDavid C. ZawiejaMitchell Institute

Discussion

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Implication

NO mediates flow effects on coronary venular permeability in animals; leaves open translation to human endothelial function.

Structured PICO

P
Population
Isolated cannulated coronary venules ranging from 30 to 70 microns in diameter
I
Intervention
Increased intraluminal flow velocity (10 and 13 mm/s) and administration of nitric oxide synthase inhibitor L-NMMA (10^-5 M) with or without L-arginine (3 x 10^-3 M)
C
Comparator
Baseline flow velocity (7 mm/s) and baseline permeability
O
Outcome
Apparent permeability coefficients of albumin (Pa)surrogate

Flow velocity acts as a physical force that modulates coronary venular permeability via a nitric oxide-dependent mechanism.

Cite This Study

Yuan et al. (1992) studied this question.

synapsesocial.com/papers/6a7e805eb2811efa75cd9b2bhttps://doi.org/10.1152/ajpheart.1992.263.2.h641
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Phasic blood flow velocity pattern in epimyocardial microvessels in the beating canine left ventricle.1986 · 86 citations
  2. 2The Dynamic Response of Vascular Endothelial Cells to Fluid Shear Stress1981 · 1,144 citations
  3. 3Shear stress-induced release of nitric oxide from endothelial cells grown on beads.1991 · 486 citations
  4. 4Shear stress and aortic histamine synthesis1978 · 54 citations
  5. 5Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo1990 · 1,865 citations