Why the study?
Data regarding the characteristics and outcomes of patients with AF and concomitant VHD were lacking despite a growing burden due to population aging.
Does concomitant valvular heart disease increase the risk of mortality, thromboembolic, and cardiac events in Japanese patients with atrial fibrillation?
Does concomitant valvular heart disease increase the risk of mortality, thromboembolic, and cardiac events in Japanese patients with atrial fibrillation?
In Japanese patients with atrial fibrillation, concomitant valvular heart disease (particularly aortic valve disease) increases the risk of heart failure hospitalization but does not significantly affect thromboembolism or mortality.
BACKGROUND: There is a growing burden of valvular heart disease (VHD) and atrial fibrillation (AF) due to population aging, but data regarding the characteristics and outcomes of patients with AF and concomitant VHD are lacking. METHODS AND RESULTS: score, and were prescribed oral anticoagulants more frequently than those without VHD. After adjusting for confounders, VHD was not associated with stroke or systemic embolism, all-cause mortality, or cardiac death. NVAF-VHD was significantly associated with an increased risk of hospitalization for heart failure (adjusted hazard ratio [HR], 1.44; 95% confidence interval [CI], 1.16-1.78), whereas VAF was not (HR, 1.28; 95% CI, 0.86-1.92). Among all types of VHD, aortic valve diseases were associated with a higher risk of cardiac events, whereas mitral valve diseases were not. CONCLUSIONS: Although VHD did not significantly affect thromboembolism or mortality, it affected cardiac events depending on type, with aortic valve diseases having higher risk, in Japanese patients with AF.
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Doi et al. (2020) studied this question.
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