Why the study?
Does heparin injection affect Ca2+ release from the sarcoplasmic reticulum in intact frog skeletal muscle fibers?
Population
Intact frog skeletal muscle fibres
Design
Preclinical
Authors
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Heparin leaves Ca2+ release intact in frog fibers; hypothesis-generating against InsP3 as EC-coupling messenger in skeletal muscle.
Does heparin injection affect Ca2+ release from the sarcoplasmic reticulum in intact frog skeletal muscle fibers?
The lack of effect of heparin on Ca2+ release argues against a major physiological role of InsP3 as a chemical messenger of excitation-contraction coupling in skeletal muscle.
Pape et al. (1988) studied this question.
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