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January 1, 1987Clinical and Experimental Hypertension

Sympathetic Modulation of the Pressure-Dependent Renin Release in Conscious Dogs

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Why the study?

Does sympathetic nerve activation modulate pressure-dependent renin release in conscious dogs?

Population

15 conscious dogs

Comparison

Stepwise reduction of renal artery pressure… vs Baseline resting state

Design

Preclinical

Authors

HKH. R. KirchheimChitose Institute of Science and TechnologyHEHeimo EhmkeElectrophysiologySFStefanie FischerUniversity of St.Gallen

Discussion

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Implication

Sympathetic adjustment of renin threshold pressure shown in dogs; leaves open human relevance and clinical translation.

Structured PICO

Does sympathetic nerve activation modulate pressure-dependent renin release in conscious dogs?

P
Population
15 conscious dogs
I
Intervention
Stepwise reduction of renal artery pressure, reflex activation of renal sympathetic nerves by common carotid occlusion (with and without intrarenal alpha-blockade using prazosin), and low dose intrarenal infusion of methoxamine
C
Comparator
Baseline resting state
O
Outcome
Renin stimulus-response curve (RSRC) and threshold pressure (Pth) for renin releasesurrogate

Renal sympathetic nerves modulate pressure-dependent renin release via alpha-adrenergic adjustment of threshold pressure.

Cite This Study

Kirchheim et al. (1987) studied this question.

synapsesocial.com/papers/6a7e9c152aa7973835973aaehttps://doi.org/10.3109/10641968709160172
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Pressure-Dependent Renin Release: The Kidney Factor in Long-Term Control of Arterial Blood Pressure in Conscious Dogs1987 · 13 citations
  2. 2Interaction between perfusion pressure and sympathetic nerves in renin release by carotid baroreflex in conscious dogs.1981 · 44 citations
  3. 3Mechanism of renin release during renal nerve stimulation in dogs1981 · 28 citations
  4. 4Interaction between neural and nonneural mechanisms controlling renin secretion rate1984 · 38 citations
  5. 5Alteration of renal baroreceptor by salt intake in control of plasma renin activity in conscious dogs1983 · 28 citations