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March 1, 1994AJP Regulatory Integrative and Comparative Physiology

Pressure-dependent renin release and arterial pressure maintenance in conscious rats

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Why the study?

Does pressure-dependent renin release play a role in mean arterial pressure maintenance in conscious normotensive rats?

Population

Normotensive intact, sympathectomized, and renal-denervated conscious rats under normal-salt diet

Comparison

Graded reductions of mean arterial pressure… vs Comparison between intact, sympathectomized, and…

Design

Preclinical

Follow-up

2 hours

Authors

SBS. BertolinoUniversity of FoggiaCJClaude JulienUniversité Claude Bernard Lyon 1IMIsac Almeida de MedeirosUniversidade Federal da Paraíba

Discussion

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Implication

Pressure-dependent renin release operates independently of sympathetic nerves in normotensive rats; leaves open its role in MAP maintenance under other conditions.

Structured PICO

Does pressure-dependent renin release play a role in mean arterial pressure maintenance in conscious normotensive rats?

P
Population
Normotensive intact (n=10), sympathectomized (n=8), and renal-denervated (n=6) conscious rats under normal-salt diet
I
Intervention
Graded reductions of mean arterial pressure (MAP) using an aortic inflatable cuff
C
Comparator
Comparison between intact, sympathectomized, and renal-denervated rats
O
Outcome
Plasma renin concentration (PRC) responses to graded reductions of MAPsurrogate

In conscious normotensive rats, pressure-dependent renin release is not spontaneously activated and operates normally without sympathetic nerves, suggesting it does not play a role in baseline MAP maintenance.

Cite This Study

Bertolino et al. (1994) studied this question.

synapsesocial.com/papers/6a81147e407ce5842fa8bbbehttps://doi.org/10.1152/ajpregu.1994.266.3.r1032
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sympathetic Modulation of the Pressure-Dependent Renin Release in Conscious Dogs1987 · 15 citations
  2. 2Blood pressure maintenance in hypertensive sympathectomized rats. II. Renin-angiotensin system and vasopressin1991 · 18 citations
  3. 3Role of renal nerves in maintaining sodium balance in unrestrained conscious rats1985 · 23 citations
  4. 4Effects of sympathectomy on blood pressure and its variability in conscious rats1990 · 47 citations
  5. 5Sustained increases in plasma epinephrine concentration do not modulate renin release1989 · 16 citations