Key result
Changing baseline blood pressure in pithed rats positively correlated with the pressor response to nerve stimulation, indicating this model should be used with caution.
Population
Pithed rats (both 2-kidney intact and nephrectomized)
Comparison
Changing baseline blood pressure by infusion of… vs Baseline state
Design
Preclinical
Authors
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Pithed rat models warrant caution in sympathetic studies with BP-altering agents; leaves open need for validation in alternative preparations.
The pithed rat model should be used with caution when studying interactions between the sympathetic nervous system and drugs that alter baseline blood pressure.
Henrion et al. (1989) studied this question. Changing baseline blood pressure (via vasopressin, enalaprilat, or hydralazine) was evaluated on Pressor responses to spinal cord stimulation. Changing baseline blood pressure in pithed rats positively correlated with the pressor response to nerve stimulation, indicating this model should be used with caution.
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