Key result
Destruction of the central nervous system by pithing produced a much greater fall in blood pressure in renal hypertensive rats than in normal rats.
Why the study?
Does destruction of the central nervous system by pithing affect blood pressure differently in renal hypertensive rats compared to normotensive rats infused with angiotensin?
Population
Normal and renal hypertensive rats
Comparison
Destruction of the central nervous system by… vs Normotensive rats infused with angiotensin…
Design
Preclinical
Authors
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Pithing causes greater BP fall in renal hypertensive rats; challenges direct angiotensin pressor role and leaves open neurogenic mechanisms for human validation.
Does destruction of the central nervous system by pithing affect blood pressure differently in renal hypertensive rats compared to normotensive rats infused with angiotensin?
The findings suggest it is unlikely that renal hypertension is due to the direct pressor action of circulating angiotensin.
Taquini et al. (1961) studied Hypertension. Destruction of the central nervous system by pithing vs. Normal rats was evaluated on Fall in blood pressure. Destruction of the central nervous system by pithing produced a much greater fall in blood pressure in renal hypertensive rats than in normal rats.
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