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August 1, 1997AJP Renal Physiology

Flow versus pressure in the control of renin release in conscious dogs

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Population

Conscious dogs (N=17 total; N=8 in protocol 1, N=9 in protocol 2)

Comparison

Reduction of renal arterial pressure in a single… vs Baseline/control conditions

Design

Preclinical

Authors

BNBenno NafzCharité - Universitätsmedizin BerlinHBHeiner K. BertholdUniversity Hospital BonnHEHeimo EhmkeElectrophysiology

Discussion

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Implication

Pressure-dependent renin release in dogs warrants caution before clinical extrapolation; leaves open RAP versus RBF mechanisms in human disease.

Structured PICO

P
Population
Conscious dogs (N=17 total; N=8 in protocol 1, N=9 in protocol 2)
I
Intervention
Reduction of renal arterial pressure (RAP) in a single step to 70 +/- 0.2 mmHg (Protocol 1) or induction of resonance between RAP and RBF using slow sinusoidal RAP waves (Protocol 2)
C
Comparator
Baseline/control conditions
O
Outcome
Renin release (plasma renin activity)surrogate

In conscious dogs, renin release is primarily dependent on decrements in renal arterial pressure rather than changes in renal blood flow.

Cite This Study

Nafz et al. (1997) studied this question.

synapsesocial.com/papers/6a7ebfd2dd8171d0d19a19d9https://doi.org/10.1152/ajprenal.1997.273.2.f200
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Elevated cardiac pressure inhibits renin release after arterial hypotension in conscious dogs1984 · 15 citations
  2. 2Sympathetic Modulation of the Pressure-Dependent Renin Release in Conscious Dogs1987 · 15 citations
  3. 3Potentiation of Renin Release by Combining Renal Arterial Constriction and β -Adrenergic Stimulation1974 · 39 citations
  4. 4Reversible Renovascular Hypertension and Renal Arterial Pressure1974 · 20 citations
  5. 5Pressure-Dependent Renin Release: The Kidney Factor in Long-Term Control of Arterial Blood Pressure in Conscious Dogs1987 · 13 citations