November 1, 1992British Journal of PharmacologyOpen Access

Inhibition of the haemodynamic effects of angiotensin II in conscious rats by AT2‐receptor antagonists given after the AT1‐receptor antagonist, EXP 3174

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Why the study?

Does the administration of AT2-receptor antagonists after AT1-receptor blockade inhibit the haemodynamic effects of angiotensin II in conscious rats?

Population

Conscious, Long Evans rats chronically instrumented for the measurement of regional haemodynamics.

Comparison

AT2-receptor antagonists administered 24 hours… vs Baseline responses in naive rats and responses…

Design

Preclinical

Follow-up

3 consecutive experimental days

Authors

RWRobert E. WiddopGeneral Cardiology SGSheila M. GardinerUniversity of Nottingham PKP.A. KempAnalytical Engineering (United States)

Discussion

Member takes

Implication

Does not support clinical use of sequential AT1/AT2 blockade; leaves open dual nonpeptide antagonists for preclinical hypertension research.

Structured PICO

Does the administration of AT2-receptor antagonists after AT1-receptor blockade inhibit the haemodynamic effects of angiotensin II in conscious rats?

Population

Conscious, Long Evans rats chronically instrumented for the measurement of regional haemodynamics (total n=20 across three groups: n=10, n=6, n=4).

Intervention

AT2-receptor antagonists (PD 123319 10 mg kg-1 i.v. or PD 123177) administered 24 hours after the AT1-receptor antagonist EXP 3174 (1 mg kg-1 i.v.).

Comparator

Baseline responses in naive rats and responses to EXP 3174 alone.

Outcome

Haemodynamic responses to angiotensin II (125 pmol kg-1, i.v.) and noradrenaline (1 nmol kg-1, i.v.).surrogate

AT2-receptor antagonists further inhibit the haemodynamic effects of angiotensin II when given 24 hours after AT1-receptor blockade, suggesting potential therapeutic advantages for nonpeptide antagonists acting at both receptors.

Cite This Study

Widdop et al. (1992) studied this question.

synapsesocial.com/papers/6a7eb1366cdd7a4db3026824 https://doi.org/10.1111/j.1476-5381.1992.tb14540.x

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November 1, 1992British Journal of PharmacologyOpen Access

Inhibition of the haemodynamic effects of angiotensin II in conscious rats by AT2‐receptor antagonists given after the AT1‐receptor antagonist, EXP 3174

View Full Paper

Ask AI

Bookmark

Why the study?

Does the administration of AT2-receptor antagonists after AT1-receptor blockade inhibit the haemodynamic effects of angiotensin II in conscious rats?

Population

Conscious, Long Evans rats chronically instrumented for the measurement of regional haemodynamics.

Comparison

AT2-receptor antagonists administered 24 hours… vs Baseline responses in naive rats and responses…

Design

Preclinical

Follow-up

3 consecutive experimental days

Authors

RWRobert E. WiddopGeneral Cardiology SGSheila M. GardinerUniversity of Nottingham PKP.A. KempAnalytical Engineering (United States)

Discussion

Member takes

Implication

Does not support clinical use of sequential AT1/AT2 blockade; leaves open dual nonpeptide antagonists for preclinical hypertension research.

Structured PICO

Does the administration of AT2-receptor antagonists after AT1-receptor blockade inhibit the haemodynamic effects of angiotensin II in conscious rats?

Population

Conscious, Long Evans rats chronically instrumented for the measurement of regional haemodynamics (total n=20 across three groups: n=10, n=6, n=4).

Intervention

AT2-receptor antagonists (PD 123319 10 mg kg-1 i.v. or PD 123177) administered 24 hours after the AT1-receptor antagonist EXP 3174 (1 mg kg-1 i.v.).

Comparator

Baseline responses in naive rats and responses to EXP 3174 alone.

Outcome

Haemodynamic responses to angiotensin II (125 pmol kg-1, i.v.) and noradrenaline (1 nmol kg-1, i.v.).surrogate

Cite This Study

Widdop et al. (1992) studied this question.

synapsesocial.com/papers/6a7eb1366cdd7a4db3026824 https://doi.org/10.1111/j.1476-5381.1992.tb14540.x

View Full Paper

Ask AI

Bookmark