Population
Conscious, chronically instrumented, male Long-Evans rats
Design
Preclinical
Authors
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In vivo results caution against assuming AT2 antagonist activity from binding data alone; leaves open central angiotensin receptor roles pending further validation.
In vivo assessment reveals important functional differences between putative AT2-receptor antagonists that are not apparent from binding studies.
Widdop et al. (1993) studied this question.
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