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January 1, 2016Cellular Physiology and BiochemistryOpen Access

Cardiac Contractility Modulation Attenuate Myocardial Fibrosis by Inhibiting TGF-β1/Smad3 Signaling Pathway in a Rabbit Model of Chronic Heart Failure

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Why the study?

Does cardiac contractility modulation attenuate myocardial fibrosis in a rabbit model of chronic heart failure?

Population

Rabbit model of chronic heart failure (CHF) induced 12 weeks after aortic constriction by pressure unloading

Comparison

Cardiac contractility modulation delivered to… vs Sham group and HF group (untreated)

Design

Preclinical, randomly divided

Follow-up

4 weeks

Authors

FZFeifei ZhangShihezi UniversityYDYi DangHebei Medical UniversityYLYingxiao LiKagoshima University

Discussion

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Implication

Supports CCM antifibrotic effects in HF models; extends preclinical data but leaves open human translation.

Structured PICO

Does cardiac contractility modulation attenuate myocardial fibrosis in a rabbit model of chronic heart failure?

P
Population
Rabbit model of chronic heart failure (CHF) induced 12 weeks after aortic constriction by pressure unloading
I
Intervention
Cardiac contractility modulation (CCM) delivered to the myocardium lasting six hours per day for 4 weeks
C
Comparator
Sham group and HF group (untreated)
O
Outcome
Myocardial fibrosis and collagen deposition evaluated by histology, and protein levels of collagen I, collagen III, α-SMA, MMP2, MMP9, TIMP1, TGF-β1 and Smad3surrogate

Cardiac contractility modulation attenuates myocardial fibrosis in a rabbit model of chronic heart failure, potentially by inhibiting the TGF-β1/Smad3 signaling pathway.

Cite This Study

Zhang et al. (2016) studied this question.

synapsesocial.com/papers/6a7eb4f3b71e981453627d5ahttps://doi.org/10.1159/000445624

Topics

Heart failureHFrEF treatment
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Also Consider

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  4. 4Activation of Peroxisome Proliferator-Activated Receptor γ (PPARγ) Through NF-κB/Brg1 and TGF-ß1 Pathways Attenuates Cardiac Remodeling in Pressure-Overloaded Rat Hearts2015 · 61 citations
  5. 5Pirfenidone Attenuates Cardiac Fibrosis in a Mouse Model of TAC-Induced Left Ventricular Remodeling by Suppressing NLRP3 Inflammasome Formation2013 · 158 citations