What question did this study set out to answer?

To synthesize current evidence regarding biological resectability and the utility of emerging biomarkers in perioperative decision-making for pancreatic ductal adenocarcinoma.

August 14, 2026Annali Italiani di ChirurgiaOpen Access

The Concept of Biological Resectability in Pancreatic Ductal Adenocarcinoma — An Updated Narrative Review

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To synthesize current evidence regarding biological resectability and the utility of emerging biomarkers in perioperative decision-making for pancreatic ductal adenocarcinoma.
Conducted a structured literature search across PubMed/MEDLINE, Embase, and Web of Science for studies published between January 2017 and March 2026, alongside seminal earlier publications.
Prioritized clinical practice guidelines, consensus statements, meta-analyses, randomized controlled trials, prospective cohort studies, and multicenter series.
Qualitatively synthesized the evidence and categorized biomarkers according to clinical maturity.
Demonstrated that many anatomically resectable tumors harbor aggressive biology linked to occult metastasis, early postoperative recurrence, and minimal benefit from upfront surgery.
Identified carbohydrate antigen 19-9 (CA 19-9) as the most clinically established biomarker, while circulating tumor DNA (ctDNA) showed strong potential for molecular staging and risk stratification.
Found that transcriptomic profiling, radiomics, and PET-derived biomarkers provide valuable tumor biology insights but remain largely investigational pending prospective standardization.

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Implication

Narrative review highlights biological resectability and biomarker integration in pancreatic ductal adenocarcinoma, suggesting improved surgical selection over purely anatomical staging.

Cite This Study

Lampropoulos et al. (2026) studied this question.

synapsesocial.com/papers/6a7ec735b70b84ec8b91353e https://doi.org/10.62713/aic.4732

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Implication

Narrative review highlights biological resectability and biomarker integration in pancreatic ductal adenocarcinoma, suggesting improved surgical selection over purely anatomical staging.

The Concept of Biological Resectability in Pancreatic Ductal Adenocarcinoma — An Updated Narrative Review

Key Points

Discussion

Implication

Cite This Study

The Concept of Biological Resectability in Pancreatic Ductal Adenocarcinoma — An Updated Narrative Review

Key Points

Discussion

Implication

Cite This Study

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