January 1, 2022Oxidative Medicine and Cellular LongevityOpen Access

Nauclea orientalis (L.) Bark Extract Protects Rat Cardiomyocytes from Doxorubicin‐Induced Oxidative Stress, Inflammation, Apoptosis, and DNA Fragmentation

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Why the study?

The therapeutic efficacy of doxorubicin is hampered by dose-dependent cardiotoxicity, prompting evaluation of Nauclea orientalis aqueous bark extract as a countermeasure.

Does Nauclea orientalis bark extract prevent doxorubicin-induced cardiotoxicity in Wistar rats?

Population

Wistar rats

Comparison

Nauclea orientalis bark extract plus doxorubicin vs doxorubicin alone, dexrazoxane, and controls

Design

Preclinical animal study

Follow-up

2 weeks

Authors

JSJayasinghe Arachchige Nirosha SandamaliUniversity of Ruhuna RHRuwani Punyakanthi HewawasamUniversity of Ruhuna KJKamani Ayoma Perera Wijewardana JayatilakaUniversity of Ruhuna

Discussion

Member takes

Implication

Should not change anthracycline cardioprotection practice; leaves open clinical testing of this bark extract.

Structured PICO

Does Nauclea orientalis bark extract prevent doxorubicin-induced cardiotoxicity in Wistar rats?

Population

Wistar rats

Intervention

Aqueous bark extract of Nauclea orientalis (2.0 g/kg for 2 weeks) prior to doxorubicin (18 mg/kg on 11th day)

Comparator

Doxorubicin control (distilled water for 2 weeks + doxorubicin 18 mg/kg on 11th day), positive control (dexrazoxane), plant extract control, and normal control

Outcome

Protection from doxorubicin-induced oxidative stress, inflammation, apoptosis, and DNA fragmentation (measured by cardiac biomarkers, lipid peroxidation, antioxidant parameters, histopathology, myeloperoxidase, TNF α, caspase-3, Bcl-2, and TUNEL)surrogate

Aqueous bark extract of Nauclea orientalis attenuates doxorubicin-induced cardiotoxicity in a rat model by reducing oxidative stress, inflammation, and apoptosis.

Cite This Study

Sandamali et al. (2022) studied this question.

synapsesocial.com/papers/6a7ed88f14ec6a5b094f7e58 https://doi.org/10.1155/2022/1714841

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Nauclea orientalis (L.) Bark Extract Protects Rat Cardiomyocytes from Doxorubicin‐Induced Oxidative Stress, Inflammation, Apoptosis, and DNA Fragmentation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Nauclea orientalis (L.) Bark Extract Protects Rat Cardiomyocytes from Doxorubicin‐Induced Oxidative Stress, Inflammation, Apoptosis, and DNA Fragmentation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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