What question did this study set out to answer?

To investigate the mechanism of falsely normal serum amylase levels in patients with clinical acute pancreatitis and severe hypertriglyceridemia.

September 10, 1973JAMA

Suppression of Amylase Activity by Hypertriglyceridemia

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Authors

RFR. FallatUniversity of Cincinnati

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Implication

Case series reveals in vitro suppression of serum amylase by hypertriglyceridemia in acute pancreatitis, indicating serial saline dilution unmasks true elevated enzyme levels.

Key Points

To investigate the mechanism of falsely normal serum amylase levels in patients with clinical acute pancreatitis and severe hypertriglyceridemia.
Evaluated serum amylase activity in three patients (N=3) presenting with clinical pancreatitis, lactescent plasma, and type V hyperlipoproteinemia.
Assessed in vitro assay interference across plasma triglyceride concentrations ranging from 500 to 6,000 mg/100 ml.
Performed serial dilutions of hyperlipemic serum with saline solution to measure uninhibited amylase levels.
Plasma triglyceride levels between 500 and 6,000 mg/100 ml produced grossly turbid plasma that caused in vitro interference, suppressing measurable amylase activity in undiluted serum.
Serial dilution with saline solution eliminated triglyceride interference, revealing elevated actual amylase levels in all three clinical pancreatitis patients who initially showed normal undiluted values.

Cite This Study

R. Fallat (1973) studied this question.

synapsesocial.com/papers/6a7ee91fe7861671be8ed027 https://doi.org/10.1001/jama.1973.03220390031007

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Implication

Case series reveals in vitro suppression of serum amylase by hypertriglyceridemia in acute pancreatitis, indicating serial saline dilution unmasks true elevated enzyme levels.

Suppression of Amylase Activity by Hypertriglyceridemia

Discussion

Member takes

Implication

Key Points

Cite This Study

Suppression of Amylase Activity by Hypertriglyceridemia

Discussion

Member takes

Implication

Key Points

Cite This Study

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