Why the study?
What are the clinical characteristics and outcomes of patients who develop endocarditis despite receiving antimicrobial prophylaxis?
Population
52 cases of apparent endocarditis prophylaxis failure reported to a national registry established by the…
Design
Case_series
Authors
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Failures often involve non-recommended regimens; leaves open whether AHA adherence prevents most viridans streptococcal cases.
What are the clinical characteristics and outcomes of patients who develop endocarditis despite receiving antimicrobial prophylaxis?
Endocarditis prophylaxis failures can occur even when the infecting organism is susceptible to the antibiotics used, though most failures in this registry involved non-guideline-directed regimens.
David T. Durack (1983) studied this question.
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