Key result
High office blood pressure variability (highest vs lowest tertile) was associated with an increased risk of incident CVD events in older adults without prior CVD (HR 1.36; 95% CI 1.08-1.70; P=0.01).
Why the study?
High office blood pressure variability increases CVD risk in midlife, but its impact in older adults without previous CVD was unknown.
Does high long-term office blood pressure variability increase the risk of cardiovascular disease events in community-dwelling elderly without previous CVD?
Population
16 475 participants aged 70+ years (65+ for US minorities) without baseline CVD surviving to year 2
Comparison
Highest tertile vs lowest tertile of office blood pressure variability
Design
Post hoc analysis of the ASPREE randomized controlled trial
Authors
Loading...
Should not yet change practice; leaves open whether targeting OBPV reduces first CVD in healthy older adults.
Cohort (n=16,475)
Yes
Does high long-term office blood pressure variability increase the risk of cardiovascular disease events in community-dwelling elderly without previous CVD?
Hazard Ratio: 1.36 (95% CI 1.08–1.7)
p-value: p=0.01
High long-term visit-to-visit office blood pressure variability is an independent risk factor for incident cardiovascular events and mortality in healthy older adults without prior CVD.
Ernst et al. (2020) conducted a cohort in Healthy older adults without previous cardiovascular disease (n=16,475). High office blood pressure variability (highest tertile) vs. Lowest tertile of office blood pressure variability was evaluated on Incident CVD events (HR 1.36, 95% CI 1.08-1.70, p=0.01). High office blood pressure variability (highest vs lowest tertile) was associated with an increased risk of incident CVD events in older adults without prior CVD (HR 1.36; 95% CI 1.08-1.70; P=0.01).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: