Lnk Inhibits Tpo–mpl Signaling and Tpo-mediated Megakaryocytopoiesis
Population
Hematopoietic cell lines, primary hematopoietic cells, and Lnk-deficient mice vs wild-type mice
Comparison
Lnk overexpression or Lnk deficiency vs Wild-type mice or control cells
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Hypothesis-generating in Lnk-deficient mice; extends Tpo signaling models but leaves open human relevance and should not change practice.
Structured PICO
P
Population
Hematopoietic cell lines (32D cells expressing mpl), primary hematopoietic cells (bone marrow-derived megakaryocyte culture), and Lnk-deficient mice vs wild-type mice
I
Intervention
Lnk overexpression or Lnk deficiency (genetic manipulation)
C
Comparator
Wild-type mice or control cells
O
Outcome
Tpo-mediated cell proliferation, endomitosis, and megakaryocyte growthsurrogate
Lnk negatively modulates mpl signaling pathways and is important for regulating Tpo-mediated megakaryocytopoiesis in vivo.
Cite This Study
Tong et al. (2004) studied this question.