Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 31, 2013Seminars in Thrombosis and Hemostasis

Local Verification and Assignment of Mean Normal Prothrombin Time and International Sensitivity Index Values across Various Instruments: Recent Experience and Outcome from North America

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does a local verification process accurately assign ISI and MNPT for unsupported reagent/instrument combinations compared to a reference method?

Population

25 random normal donor samples and 13 warfarin pools created from stable warfarin patient plasma

Comparison

RecombiPlasTin 2G evaluated on unsupported… vs ACL TOP 700 (reference method)

Design

Other

Authors

JTJulie I TangeMayo ClinicDGDiane E. GrillInterventional CardiologyCKChristopher KochGeorge Fox University

Discussion

Loading...

Member takes

Implication

Local verification of ISI/MNPT may ensure accurate INR on unsupported pairs; leaves open standardized calibration protocols.

Structured PICO

Does a local verification process accurately assign ISI and MNPT for unsupported reagent/instrument combinations compared to a reference method?

P
Population
25 random normal donor samples and 13 warfarin pools (INR range: 1.3-3.9) created from stable warfarin patient plasma
I
Intervention
RecombiPlasTin 2G (R2G) evaluated on unsupported instruments (STA-R Evolution, STA Compact, and STA Satellite)
C
Comparator
ACL TOP 700 (reference method)
O
Outcome
Verification and assignment of International Sensitivity Index (ISI) and mean normal prothrombin time (MNPT)surrogate

A local verification process using normal donor samples and warfarin pools can accurately assign ISI and MNPT values for unsupported reagent/instrument combinations, ensuring accurate INR calculation.

Cite This Study

Tange et al. (2013) studied this question.

synapsesocial.com/papers/6a7f821c8ff2cc18c1681eb2https://doi.org/10.1055/s-0033-1363475
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Improving the Inter-Laboratory Harmonization of the International Normalized Ratio (INR): Utilizing the Concept of Transference to Estimate and/or Validate International Sensitivity Index (ISI) and Mean Normal Prothrombin Time (MNPT) Values and/or to Eliminate Measurement Bias2012 · 14 citations
  2. 2How to Generate a More Accurate Laboratory-Based International Normalized Ratio: Solutions to Obtaining or Verifying the Mean Normal Prothrombin Time and International Sensitivity Index2018 · 35 citations
  3. 3Improving the harmonisation of the International Normalized Ratio (INR): time to think outside the box?2010 · 28 citations
  4. 4Simplified Method for International Normalized Ratio (INR) Derivation Based on the Prothrombin Time/INR Line: An International Study2010 · 21 citations
  5. 5Standardization of the INR: How Good Is Your Laboratory's INR and Can It Be Improved?2008 · 46 citations