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June 1, 2013Circulation Cardiovascular InterventionsOpen Access

Comparison of Manual Thrombus Aspiration With Rheolytic Thrombectomy in Acute Myocardial Infarction

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Why the study?

Does rheolytic thrombectomy reduce residual thrombus burden compared to manual thrombus aspiration in patients with acute myocardial infarction?

Population

80 patients with acute myocardial infarction undergoing infarct artery stenting

Comparison

Rheolytic thrombectomy before infarct artery… vs Manual thrombus aspiration before infarct artery…

Design

RCT, Randomized

Follow-up

6 months

Authors

GPGuido ParodiInterventional / Structural CardiologyRVRenato ValentiAzienda Ospedaliero-Universitaria CareggiAngela MiglioriniAngela MiglioriniInterventional / Structural Cardiology

Discussion

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Implication

Rheolytic thrombectomy is not superior to manual aspiration for residual thrombus reduction; challenges routine mechanical thrombectomy in AMI.

Structured PICO

Does rheolytic thrombectomy reduce residual thrombus burden compared to manual thrombus aspiration in patients with acute myocardial infarction?

P
Population
80 patients with acute myocardial infarction undergoing infarct artery stenting
I
Intervention
Rheolytic thrombectomy (RT) before infarct artery stenting
C
Comparator
Manual thrombus aspiration (MTA) before infarct artery stenting
O
Outcome
Residual thrombus burden by optical coherence tomographysurrogate

Rheolytic thrombectomy did not significantly reduce overall residual thrombus burden by OCT compared to manual aspiration, though it may reduce the incidence of large residual thrombus and improve reperfusion markers.

Cite This Study

Parodi et al. (2013) studied this question.

synapsesocial.com/papers/6a7fbaa06d8c9e2704ec9ed2https://doi.org/10.1161/circinterventions.112.000172

Topics

Percutaneous coronary intervention
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Thrombolysis in Myocardial Infarction (TIMI) Trial1985 · 3,192 citations
  2. 2Consensus Standards for Acquisition, Measurement, and Reporting of Intravascular Optical Coherence Tomography Studies2012 · 1,888 citations
  3. 3Role of adjunctive thrombectomy and embolic protection devices in acute myocardial infarction: a comprehensive meta-analysis of randomized trials2008 · 262 citations
  4. 4Comparison of AngioJet Rheolytic Thrombectomy Before Direct Infarct Artery Stenting With Direct Stenting Alone in Patients With Acute Myocardial Infarction2010 · 196 citations
  5. 5Combination Therapy With Abciximab Reduces Angiographically Evident Thrombus in Acute Myocardial Infarction2001 · 494 citations