Why the study?
Conflicting findings had been reported regarding the link between plasma trimethylamine N-oxide level and prognosis in patients with heart failure.
Is elevated plasma TMAO level associated with an increased risk of MACEs and all-cause mortality in patients with heart failure?
Population
6879 patients with heart failure across seven prospective studies
Comparison
Higher vs lower plasma TMAO levels
Design
Meta-analysis of prospective clinical studies
Follow-up
Median 5.0 years
Authors
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May identify higher-risk HF patients beyond eGFR; leaves open whether TMAO-lowering therapies improve outcomes.
Is elevated plasma TMAO level associated with an increased risk of MACEs and all-cause mortality in patients with heart failure?
Elevated plasma TMAO levels are associated with an increased risk of MACEs and all-cause mortality in patients with heart failure, an effect only partially mediated by renal dysfunction.
Li et al. (2020) studied this question.
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