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Ventricular dyssynchrony is a dynamic phenomenon that adversely affects hemodynamics and prognosis in congestive heart failure, which can be improved by cardiac resynchronization therapy.
Since the 1990s, it has been well known that many adverse effects on hemodynamics are induced by ventricular dyssynchrony [1] and that it is related to prognosis in patients with congestive heart failure [2]. Cardiac resynchronization therapy (CRT) is an encouraging treatment for patients with congestive heart failure, especially for those showing wide QRS and ventricular dyssynchrony. Several clinical trials, such as MIRACLE trial, COMPANION trial, and Care-HF trial [3] demonstrated that CRT improves prognosis in patients with congestive heart failure.
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Chisato Izumi (2013) studied this question.
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