Key result
Universal Resonance Model proposes biological information resides in the temporal structure of physiological variables.
Why the study?
To develop a measurement principle within The Universal Resonance Model positing that biological information resides in temporal structure, variability, stability, and directional evolution rather than solely in absolute levels.
Design
Concept note
Proposes temporal variability as a novel physiological signal; extends URM conceptually but leaves open clinical utility pending empirical validation.
This concept note develops a measurement principle within The Universal Resonance Model (URM): biological information may reside not only in the absolute level or mean of a physiological variable, but also in its temporal structure, variability, stability, and directional evolution. Heart-rate variability and repeated saccadic-latency measurements in Parkinson’s disease are used as separate methodological illustrations. The paper distinguishes absolute levels, within-signal dynamics, and coordinated dynamics across coupled biological regulatory systems. It proposes that temporal changes become specifically relevant to URM when they are associated with altered cross-system coordination, instability gain, or transition risk. The article presents a conceptual and testable extension of URM. It does not establish a diagnostic biomarker, clinical monitoring method, treatment recommendation, or validated early-warning signal. No new experimental or clinical data were generated or analyzed.
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Anita Domargård (2026) studied this question. The Universal Resonance Model proposes that biological information resides in the temporal structure and variability of physiological variables, though no new clinical data were generated.
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