The Universal Resonance Model of Disease: A Primer on Cross-System Instability, Early-Warning Signals, and Predictive Transitions

This preprint introduces the Universal Resonance Model (URM), a cross-system dynamical framework for understanding how physiological networks approach critical transitions. URM integrates three universal early-warning signatures—rising variance (σ²↑), increasing temporal autocorrelation (ρ(τ)↑), and softening of the dominant recovery exponent (|λ₁|↓)—and shows how they appear across immune, cardiac, autonomic, endocrine, and metabolic systems. The paper outlines the mathematical foundations of URM, proposes clinical implications for anticipatory medicine, and defines clear falsification pathways. It is intended as a primer and reference text for researchers interested in instability metrics and predictive health. URM is a map of dynamics—not the territory itself; clinical reality also contains human complexity that must be co-created in the clinical encounter.