Why the study?
Do high-carbohydrate and high-fat meals induce postprandial endothelial dysfunction via oxidative stress in human subjects?
Do high-carbohydrate and high-fat meals induce postprandial endothelial dysfunction via oxidative stress in human subjects?
This review highlights that postprandial spikes in glucose and triglycerides following high-carbohydrate or high-fat meals impair endothelial function, likely mediated by oxidative stress, emphasizing the vascular impact of dietary choices.
May support dietary caution in T2DM; leaves open need for interventional trials on oxidative mediation.
Endothelial dysfunction is a turning point in the initiation and development of atherosclerosis and its complications and is predictive of future cardiovascular events. Ingestion of high-carbohydrate or high-fat meals often results in postprandial hyperglycaemia and/or hypertriacylglycerolaemia that may lead to a transient impairment in endothelial function. The present review will discuss human studies evaluating the impact of high-carbohydrate and high-fat challenges on postprandial endothelial function as well as the potential role of oxidative stress in such postprandial metabolic alterations. Moreover, the present review will differentiate the postprandial endothelial and oxidative impact of meals rich in varying fatty acid types.
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Lacroix et al. (2012) studied this question.
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