Hypoxia induces reversible changes in the pre-ejection period and left ventricular ejection time ratio.
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Caution advised when interpreting systolic time intervals in hypoxia; leaves open their validation as LV function markers.
Using 1/PEP 2 (PEP = pre‐ejection period of the heart) and PEP/LVET‐ratio (LVET = left ventricular ejection time) as parameters it was shown that 1/PEP 2 increased and PEP/LVET decreased during hypoxia, and when pure oxygen breathing was started, the hypoxic changes were reversed.
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Rasmussen et al. (1974) studied this question.
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