Key result
Endomyocardial biopsy aids diagnosis and prognosis of ICI myocarditis when non-invasive tests are uncertain.
Why the study?
The role of endomyocardial biopsy in the diagnosis, prognostication, and understanding of mechanisms for immune checkpoint inhibitor myocarditis needed to be identified.
Does endomyocardial biopsy improve the diagnosis and prognostication of immune checkpoint inhibitor associated myocarditis in patients receiving immune checkpoint inhibitors?
Does endomyocardial biopsy improve the diagnosis and prognostication of immune checkpoint inhibitor associated myocarditis in patients receiving immune checkpoint inhibitors?
Endomyocardial biopsy provides definitive diagnostic and emerging prognostic value in immune checkpoint inhibitor myocarditis, particularly when non-invasive imaging is inconclusive.
No takes yet. Share an insight, caveat, or question.
Should not yet change practice; leaves open EMB’s incremental role when imaging fails and whether CD68+ macrophages independently alter ICI decisions.
Ostos-Mendoza et al. (2026) conducted a review in Immune checkpoint inhibitor associated myocarditis. Endomyocardial biopsy was evaluated. Endomyocardial biopsy remains valuable for diagnosing immune checkpoint inhibitor myocarditis when non-invasive tests are uncertain, and emerging evidence suggests it can help determine prognosis.
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