May 30, 2008AJP Heart and Circulatory Physiology
Windkesselness of coronary arteries hampers assessment of human coronary wave speed by single-point technique
Why the study?
Does the single-point technique accurately estimate local coronary wave speed under conditions commonly encountered in the catheterization laboratory?
Population
29 patients undergoing cardiac catheterization, with measurements taken in a distal segment of a normal…
Comparison
Assessment of local arterial wave speed using a… vs Measurements at rest versus during…
Design
Other
Authors
Discussion
Loading...
Member takes
Implication
Single-point coronary wave speed estimation should not be used in the cath lab; challenges prior wave-intensity studies and leaves validation of alternatives open.
Structured PICO
Does the single-point technique accurately estimate local coronary wave speed under conditions commonly encountered in the catheterization laboratory?
P
Population
29 patients undergoing cardiac catheterization, with measurements taken in a distal segment of a normal reference vessel and downstream of a single stenosis before and after revascularization.
I
Intervention
Assessment of local arterial wave speed (SPc) using a single-point technique derived from intracoronary pressure (Pd) and Doppler velocity (U) at rest and during adenosine-induced hyperemia (with conduit vessel tone minimized by nitroglycerin).
C
Comparator
Measurements at rest versus during adenosine-induced hyperemia, and before versus after stent placement.
O
Outcome
Changes in calculated local arterial wave speed (SPc) and its correlation with microvascular resistance (MR) and intracoronary pressure (Pd).surrogate
The single-point technique is inappropriate for estimating local wave speed in coronary vessels due to the confounding 'windkessel' effect of the coronary arteries.
Cite This Study
Kolyva et al. (2008) studied this question.