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June 5, 2015AtherosclerosisOpen Access

Angiopoietin-2 blocking antibodies reduce early atherosclerotic plaque development in mice

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Why the study?

Does Ang-2 blocking antibody treatment reduce atherosclerotic plaque development in hypercholesterolemic mice?

Population

Hypercholesterolemic (low-density lipoprotein receptor apolipoprotein B) mice subjected to high-cholesterol…

Comparison

Ang-2 blocking antibody treatment during weeks 4-8 vs No Ang-2 blocking antibody treatment

Design

Preclinical

Follow-up

8 weeks

Authors

TTThomas TheelenRadboud University NijmegenJLJari P. LappalainenUniversity of Eastern FinlandJSJudith C. SluimerMaastricht University Medical Centre

Discussion

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Implication

Hypothesis-generating in murine atherosclerosis; leaves open translation to human disease.

Structured PICO

Does Ang-2 blocking antibody treatment reduce atherosclerotic plaque development in hypercholesterolemic mice?

P
Population
Hypercholesterolemic (low-density lipoprotein receptor(-/-) apolipoprotein B(100/100)) mice subjected to high-cholesterol diet for eight weeks with a peri-adventitial collar placed around the carotid arteries
I
Intervention
Ang-2 blocking antibody treatment during weeks 4-8
C
Comparator
No Ang-2 blocking antibody treatment
O
Outcome
Atherosclerotic plaque size and stable plaque characteristics in aortic root, carotid arteries and brachiocephalic arteriessurrogate

Ang-2 blockage decreases early fatty streak formation and plasma triglycerides in a mouse model of atherosclerosis, suggesting a potential benefit in early atherogenesis.

Cite This Study

Theelen et al. (2015) studied this question.

synapsesocial.com/papers/6a80ab2e2cf87dafd7c8b1d8https://doi.org/10.1016/j.atherosclerosis.2015.05.018
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